S8572

Anti-STIM2 兔抗

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-stromal interaction molecule 2
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~100 kDa
• 物種活性: human, mouse, rat
• 濃度: ~1.0 mg/mL
• 技術: western blot: 0.1-0.2 μg/mL using whole extract of mouse brain; western blot: 0.5-1.0 μg/mL using rat brain; western blot: 0.5-1.0 μg/mL using whole extracts of human U87 cells
• UniProt登錄號: Q9P246
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... STIM2(57620) ; mouse ... Stim2(116873) ; rat ... Stim2(117087)

描述

一般說明

STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.

免疫原

synthetic peptide corresponding to amino acids 812-833 of human STIM2, conjugated to KLH. The corresponding sequence is identical in rat and mouse.

應用

Anti-STIM2 antibody produced in rabbit has been used in western blotting.

生化／生理作用

STIM (stromal interaction molecule) required for the regulation of store-operated Ca²⁺ influx. Store-operated calcium entry is mediated by Ca²⁺ release-activated Ca²⁺ (CRAC) channels, following Ca²⁺ depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca²⁺ entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca²⁺ entry.

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)