S8567

SU 4312

≥98% (HPLC)

• 同義詞: 3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
• 經驗公式（希爾表示法）: C₁₇H₁₆N₂O
• CAS號碼: 5812-07-7
• 分子量：: 264.32
• MDL號碼: MFCD00118147
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278803
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: orange
• 溶解度: DMSO: >10 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23
• InChI: 1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
• InChI 密鑰: UAKWLVYMKBWHMX-RVDMUPIBSA-N
• 基因資訊: human ... FLT1(2321)

描述

應用

SU 4312 was used to study angiogenesis during development of zebrafish embryos.²

生化／生理作用

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.¹

SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他說明

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves