S6699

β-Synuclein P123H histidine-tagged human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

• 同義詞: SNCB
• MDL號碼: MFCD08705537
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 重組細胞: expressed in E. coli
• 品質等級: 200
• 化驗: ≥90% (SDS-PAGE)
• 形狀: lyophilized powder
• UniProt登錄號: Q16143
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 基因資訊: human ... SNCB(6620)

描述

生化／生理作用

Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.

外觀

Lyophilized from a 0.2 μm filtered solution.

重構

Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable