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Key Documents

S4776

Sigma-Aldrich

Somatotropin from human pituitary

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

同義詞:

STH

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.32

重組細胞

expressed in E. coli

品質等級

無菌

non-sterile

化驗

≥95% (SDS-PAGE)

形狀

lyophilized powder

效力

0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50

分子量

predicted mol wt ~22 kDa

drug control

Home Office Schedule 4.2

雜質

endotoxin, tested

溶解度

PBS: 0.100 mL, clear, colorless (with 0.1% BSA )

UniProt登錄號

運輸包裝

ambient

儲存溫度

−20°C

基因資訊

一般說明

Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.

應用

Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.

生化/生理作用

Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.

外觀

Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.

重構

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Yun Pang et al.
Kidney international, 90(6), 1357-1367 (2016-10-18)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by overproduction of numerous autoantibodies. Many studies have sought to identify such biomarkers to distinguish patients with active lupus nephritis from SLE patients without renal involvement. Because antibodies to complement C1q
Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review
Christina Southern Reh
Clinical Pharmacology & Biopharmaceutics (2010)
Lina Pednekar et al.
Frontiers in immunology, 7, 600-600 (2017-01-10)
Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T-cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions. Along with its role in HIV-1 pathogenesis through complement opsonization of the virus, DC-SIGN
Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
Kawamata, Yuji, et al
Journal of Reproduction and Development (2001)

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