S4447

α-Synuclein E46K 人

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

• 同義詞: NACP (Non-a-beta component of Alzheimer disease amyloid, precursor), PARK1, PARK4, PD1, non A4 component of amyloid precursor
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 重組細胞: expressed in E. coli
• 品質等級: 200
• 化驗: ≥90% (SDS-PAGE)
• 形狀: lyophilized powder
• 分子量: apparent mol wt 19-20 kDa
• UniProt登錄號: P37840
• 相容性: for use with ABI StepOnePlus
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 基因資訊: human ... SNCA(6622)

描述

生化／生理作用

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu⁴⁶-to-Lys (E46K) substitution in the amino-terminal region of the protein.

Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)