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重要文件

S4441

Sigma-Aldrich

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

同義詞:

1-异硫氰酸基-4-(甲亚磺酰基)-丁烷

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About This Item

經驗公式(希爾表示法):
C6H11NOS2
CAS號碼:
分子量::
177.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

DL-萝卜硫素, ≥90% (HPLC), synthetic, liquid

生物源

synthetic

品質等級

化驗

≥90% (HPLC)

形狀

liquid

溶解度

DMSO: soluble 40 mg/mL
H2O: insoluble

相容性

for use with ABI 7500

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

InChI 密鑰

SUVMJBTUFCVSAD-UHFFFAOYSA-N

應用

用DL-萝卜硫素处理LNCaP前列腺癌细胞以研究其对雄激素受体的作用。用DL-萝卜硫素处理大鼠对研究其对马拉硫磷毒性的影响。

生化/生理作用

具有抗癌特性的II相解毒酶的选择性诱导物。在十字花科蔬菜(包括西兰花)中发现的有机硫化合物。
萝卜硫素是一种在十字花科蔬菜中发现的抗癌、抗微生物和抗糖尿病化合物。它可诱导产生解毒酶,例如可引起异生素转化的醌还原酶和谷胱甘肽S-转移酶。萝卜硫素还可增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。它通过抑制LPS介导的iNOS、COX-2、IL-1β 和TNF-α的表达来调节炎症反应。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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A Kenneth MacLeod et al.
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Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of NRF2 activity. Here we utilise four members of the aldo-keto
Verena Jeschke et al.
Frontiers in plant science, 8, 1995-1995 (2017-12-07)
Multiple lepidopteran larvae feed successfully on plants containing glucosinolates despite the diverse array of toxic and deterrent breakdown products, such as isothiocyanates (ITCs), formed upon plant damage. While much is known about how specialist lepidopterans metabolize and tolerate glucosinolates, there
Carmela Fimognari et al.
Mutation research, 635(2-3), 90-104 (2006-12-01)
A number of natural compounds with inhibitory effects on tumorigenesis have been identified from our diet. Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous
Masayoshi Yamaguchi et al.
International journal of molecular medicine, 38(6), 1940-1946 (2016-11-15)
β-caryophyllene, which is a constituent of many essential oils, has been known to be a selective agonist of the cannabinoid receptor type-2 and to exert cannabimimetic anti-inflammatory effects in animals. The effects of β-caryophyllene on macrophages have not been investigated
Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis.
Áislan de Carvalho Vivarini et al.
Frontiers in immunology, 8, 1127-1127 (2017-09-30)

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