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一般說明
L-硒代蛋氨酸(SeMet)是硒的有机形式,存在于耐金属贪铜菌中。
應用
L-硒代蛋氨酸可用于:
- 用于日本青鳉胚胎的毒性研究
- 研究其对怀孕长尾猕猴硒状态指标的影响(食蟹猴)
- 为单波长反常色散(SAD)相位标记蛋白质
硒-L-蛋氨酸已用于:
- 作为处理日本青鳉鱼胚胎的非化学应激源
- 标记蛋白质,用于单波长异常色散(SAD)定相
- 研究硒-L-蛋氨酸对 4T1 小鼠乳腺癌的分布和抑制作用
生化/生理作用
L-硒代蛋氨酸(SeMet)能够抑制特应性皮炎(AD)样皮损。它还能抑制总免疫球蛋白E (IgE)和白介素4 (IL-4)的表达。它可通过饮食被鱼类吸收,因此会造成生态毒性。
硒-L-蛋氨酸显示出抗氧化活性,并且已表明能增加内皮细胞中谷胱甘肽过氧化物酶的活性。 谷胱甘肽过氧化物酶保护细胞免受氧化损伤,例如DNA 链断裂、突变和基于蛋白酪氨酸的信号传导的干扰,以及由于过量亚硝酸盐引起的3-硝基酪氨酸形成的其他蛋白质功能。向癌细胞系(MCF-7/S 乳腺癌,DU-145 前列腺癌细胞和UACC-375 黑素瘤)给予硒-L-甲硫氨酸处理,导致细胞凋亡和异常有丝分裂。这些人肿瘤细胞系在微摩尔范围(45至130μM)内表现出硒代蛋氨酸的剂量依赖性生长抑制,而正常成纤维细胞的生长抑制需要 1mM 硒代蛋氨酸。
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類(WGK)
WGK 3
閃點(°F)
250.3 - 346.3 °F
閃點(°C)
121.3 - 174.6 °C
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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