推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
InChI
1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChI 密鑰
DMWVGXGXHPOEPT-UHFFFAOYSA-N
應用
Src抑制剂-1可用于Src激酶介导的细胞信号转导研究。
生化／生理作用
Src抑制剂-1是一种有效的、竞争性的双重位点（ATP和肽结合）Src激酶抑制剂。Src抑制剂-1是Src激酶抑制的“金标准”之一。研究已经显示通过Src-I1与PP1或PP2一起使用可抑制Src家族激酶。Src抑制剂-1是酪氨酸激酶Src家族的选择性竞争性抑制剂（分别对于Src和Lck的IC50为44nM和88nM）。Src抑制剂-1可以更高的浓度抑制VEGFR2和c-fms酪氨酸激酶（IC50分别为0.32 μM和30 μM）。
除Src激酶外，一些Src抑制剂也可抑制Abl激酶、Lck、Csk和Yes蛋白的活性，因此研究人员正在探索将其作为可行的抗癌药物的可能性。
特點和優勢
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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