RAB0490

Human soluble TNF Receptor 2 ELISA Kit

for serum, plasma for serum, plasma, cell culture supernatant and urine

• 同義詞: sTNFRII
• 分類程式碼代碼: 41116158
• NACRES: NA.32

屬性

• 物種活性: human
• 包裝: kit of 96 wells (12 strips x 8 wells)
• 技術: ELISA: suitable; capture ELISA: suitable
• 輸入: sample type plasma; sample type cell culture supernatant(s); sample type plasma; sample type serum; sample type urine; sample type serum
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 5 pg/mL; standard curve range: 2.74-2000 pg/mL
• 檢測方法: colorimetric
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

一般說明

The Human sTNF RII ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human sTNF RII in serum, plasma, cell culture supernatants and urine.

免疫原

Recombinant Human TNF RII

應用

请参考Protocol了解详情。

生化／生理作用

Tumor necrosis factor receptor 2 (TNFR2) plays a vital role in inducing signals for various cellular process, including proliferation of thymocytes and peripheral T cells, T cell secretion of granulocyte-macrophage colony-stimulating factor, inhibition of early hematopoiesis, and the inactivation and clearance of TNF by the kidney. Mutation in the gene leads to hematopoietic cell malignancies, neuroblastoma, glioma, cervical and ovarian carcinoma. TRAF2 interacts with TNFR2 and activates NF-kappa B (NF-κB) pathway. TNFR2, which lacks death domains, modulates the effect of other death receptor TNFR1, which induces T cell death. TNFR2 plays an essential role in TNF-α–induced leukocyte-endothelial interaction. TNFR2 is considered as a potential therapeutic alternative, as it has capacity to nullify the common side effects associated with drugs targeting TNF-α or p55.

其他說明

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

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• RABSTOP3 ELISA Stop Solution (Item I)
• RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
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安全資訊

• 象形圖: GHS05
• 訊號詞: Warning
• 危險聲明: H290
• 防範說明: P234 - P390
• 危險分類: Met. Corr. 1
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials