RAB0441

Phospho-Stat1 (pSer⁷²⁷) and pan-Stat1 ELISA Kit

for detection of phospho-stat1 (pSer⁷²⁷) and pan-stat1 in human or mouse cell and tissue lysates

• 分類程式碼代碼: 41116158
• NACRES: NA.32

屬性

• 物種活性: mouse, human
• 技術: ELISA: suitable; capture ELISA: suitable
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... STAT1(6772) ; mouse ... STAT1(20846)

描述

一般說明

The Phospho-Stat1 (pSer⁷²⁷) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

免疫原

Stat1 (pTyr⁷²⁷) synthetic phosphopeptide, Recombinant Human STAT1

應用

请参考Protocol了解详情。

生化／生理作用

Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Warning
• 危險聲明: H290 - H335
• 危險分類: Met. Corr. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 8A - Combustible, corrosive hazardous materials