推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, mouse, human
濃度
1 mg/mL
技術
western blot: 6.6 μg/mL using HeLa cell extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RAB11A(8766)
mouse ... Rab11a(53869)
rat ... Rab11a(81830)
一般說明
Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly.
免疫原
synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians.
應用
Anti-Rab11 has been used in western blotting and immunohistochemistry.
生化／生理作用
Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).
外觀
Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells
Wakabayashi Y, et al.
Proceedings of the National Academy of Sciences of the USA, 15087-92, 15087-15092 (2005)
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane
van de Graaf SF, et al.
Molecular and Cellular Biology, 26(1), 303-312 (2006)
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function
Muller J, et al.
PLoS ONE, 9(2) (2014)
Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells
Kallquist L, et al.
Experimental Cell Research, 316(19), 3182-3196 (2010)
Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
Gromov PS, et al.
Febs Letters, 429(3), 359-364 (1998)
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