推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D +30 to +40°, c = 0.5 in chloroform-d
顏色
white to beige
溶解度
DMSO: 25 mg/mL, clear
儲存溫度
room temp
InChI
1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1
InChI 密鑰
CAYJBRBGZBCZKO-BHGBQCOSSA-N
一般說明
芦平曲韦是一种不可逆的拟肽抑制剂，其可靶向人鼻病毒（HRV）。其之前被命名为AG7088。芦平曲韦也被发现可能涉及 体外 抗病毒活性。
生化／生理作用
芦平曲韦（AG7088）是一种不可逆的人类鼻病毒（HRV）3C蛋白酶抑制剂，其也被发现可以抑制肠病毒和诺如病毒。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
S L Binford et al.
Antimicrobial agents and chemotherapy, 49(2), 619-626 (2005-01-28)
The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variability in the
Jing Wang et al.
Journal of virology, 85(19), 10021-10030 (2011-08-05)
EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-resolution crystal structures of the EV71
Chunlong Ma et al.
ACS infectious diseases, 6(8), 2260-2270 (2020-07-22)
Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for
Kim S Robinson et al.
Science (New York, N.Y.), 370(6521) (2020-10-24)
Immune sensor proteins are critical to the function of the human innate immune system. The full repertoire of cognate triggers for human immune sensors is not fully understood. Here, we report that human NACHT, LRR, and PYD domains-containing protein 1
Sanne Boersma et al.
Cell, 183(7), 1930-1945 (2020-11-15)
RNA viruses are among the most prevalent pathogens and are a major burden on society. Although RNA viruses have been studied extensively, little is known about the processes that occur during the first several hours of infection because of a
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