PZ0305

WAY-208466 二盐酸盐

≥98% (HPLC)

• 同義詞: 3-[(3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine hydrochloride (1:2), WAY 208466 dihydrochloride, WAY208466 dihydrochloride
• 經驗公式（希爾表示法）: C₁₇H₁₈FN₃O₂S · 2HCl
• CAS號碼: 1207064-61-6
• 分子量：: 420.33
• MDL號碼: MFCD28384460
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329823827
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: H₂O: 5 mg/mL, clear (warmed)
• 儲存溫度: room temp
• SMILES 字串: CN(C)CCN1C=C(S(C2=CC=CC(F)=C2)(=O)=O)C3=CC=CN=C31
• InChI: 1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3
• InChI 密鑰: SFSFIDVAEMDPIP-UHFFFAOYSA-N

描述

生化／生理作用

WAY-208466 is a high affinity (Ki = 4.8 nM) 5-HT6 receptor agonist. In HeLa cells expressing cloned human 5-HT6, the compound induced cAMP production (EC₅₀ = 7.3 nM; Emax = 100%). WAY-208466 increases cortical GABA levels and exhibits anxiolytic activity in rat studies.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable