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Merck
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重要文件

PZ0140

Sigma-Aldrich

EBPC

≥98% (HPLC)

同義詞:

2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic acid ethyl ester, CP-10668

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About This Item

經驗公式(希爾表示法):
C14H15NO4
CAS號碼:
分子量::
261.27
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

white

溶解度

DMSO: ≥10 mg/mL

儲存溫度

room temp

SMILES 字串

CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1

InChI

1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3

InChI 密鑰

IGYRPDIWSYGHMY-UHFFFAOYSA-N

生化/生理作用

EBPC is an aldose reductase inhibitor; anti-cancer.

其他說明

air sensitive

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Eva Bresson et al.
Frontiers in pharmacology, 3, 98-98 (2012-06-02)
Prostaglandins are important regulators of female reproductive functions to which aldose reductases exhibiting hydroxysteroid dehydrogenase activity also contribute. Our work on the regulation of reproductive function by prostaglandins (PGs), lead us to the discovery that AKR1B5 and later AKR1B1were highly
E S Kang et al.
Cellular and molecular life sciences : CMLS, 62(10), 1146-1155 (2005-06-02)
Over-expression of aldose reductase (AR) has been observed in many cancer cells. To clarify the role of AR in tumor cells, we investigated the pathways mediating expression of the AR gene induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. In

文章

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

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