PZ0137

CP-471474

≥98% (HPLC)

• 同義詞: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide, PF-1626077
• 經驗公式（希爾表示法）: C₁₆H₁₇FN₂O₅S
• CAS號碼: 210755-45-6
• 分子量：: 368.38
• MDL號碼: MFCD16618408
• 分類程式碼代碼: 41121801
• PubChem物質ID: 329823722
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: DMSO: ≥20 mg/mL
• 儲存溫度: room temp
• SMILES 字串: CC(C)(NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO
• InChI: 1S/C16H17FN2O5S/c1-16(2,15(20)18-21)19-25(22,23)14-9-7-13(8-10-14)24-12-5-3-11(17)4-6-12/h3-10,19,21H,1-2H3,(H,18,20)
• InChI 密鑰: QCOQJYRPDUMCNP-UHFFFAOYSA-N

描述

生化／生理作用

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinase.

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC₅₀ efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC₅₀ > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable