PZ0115

CP-31398 二盐酸盐 水合物

≥98% (HPLC)

• 同義詞: N′-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate
• 經驗公式（希爾表示法）: C₂₂H₂₆N₄O·2HCl · xH₂O
• 分子量：: 435.39 (anhydrous basis)
• MDL號碼: MFCD17215956
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329823707
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 儲存條件: desiccated
• 顏色: yellow
• 溶解度: H₂O: ≥20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2
• InChI: 1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;
• InChI 密鑰: JXIVIAMOMIONKY-UWCBQFGESA-N
• 基因資訊: human ... TP53(7157) ; mouse ... TP53(22059) ; rat ... TP53(24842)

描述

應用

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

• to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
• to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
• to study its effects on regulation of miR-34 in PC12 cells

生化／生理作用

CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.

特點和優勢

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H413
• 防範說明: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable