PRS2447

Anti-MTBP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: predicted mol wt 104 kDa
• 物種活性: human
• 技術: immunocytochemistry: suitable; immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt登錄號: Q96DY7
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MTBP(27085)

描述

免疫原

a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.

生化／生理作用

The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.

聯結

The action of this antibody can be blocked using blocking peptide SBP2447.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable