P5052

5α-Pregnan-3α-ol-11,20-dione

powder, ≥98% (TLC)

• 同義詞: 3-Hydroxy-5α-pregnane-11,20-dione, Alfaxalone
• CAS號碼: 23930-19-0
• MDL號碼: MFCD00083468
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278637
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥98% (TLC)
• 形狀: powder
• 藥物控制: USDEA Schedule IV
• 顏色: white
• 溶解度: chloroform: ≥5 mg/mL, clear, colorless
• SMILES 字串: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
• InChI 密鑰: DUHUCHOQIDJXAT-OLVMNOGESA-N
• 基因資訊: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRG2(2566)

描述

生化／生理作用

Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P301 + P310
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves