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Merck
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重要文件

P4329

Sigma-Aldrich

1,2-二棕榈酰-sn-甘油-3-磷酰胆碱

≥99% (TLC)

同義詞:

PC, (7R)-4-羟基-N,N,N-三甲基-10-氧代-7-[(1-氧代十六烷基)氧基]- 3,5,9-三氧杂-4-磷杂二十五烷-1-铵4-氧化物, 内盐, 1,2-二十六酰--甘油基-3-磷酸胆碱, 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱, 1,2-二棕榈酰- L -卵磷脂, 1,2-双十六酰基-sn-甘油-3-磷酰胆碱, L-α-磷脂酰胆碱,二棕榈酰, L-β,γ-二棕榈酰-α-卵磷脂, PC(16:0/16:0), 二棕榈酰磷脂酰胆碱

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About This Item

經驗公式(希爾表示法):
C40H80NO8P
CAS號碼:
分子量::
734.04
EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25

生物源

synthetic

品質等級

化驗

≥99% (TLC)

形狀

powder

官能基

phospholipid

脂質類型

phosphoglycerides

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

InChI 密鑰

KILNVBDSWZSGLL-KXQOOQHDSA-N

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應用


  • (6)-对伞花烃钌(II)配合物对模拟癌症和健康细胞膜的Langmuir单分子膜的影响与其毒性无关。:该研究调查了钌(II)配合物与Langmuir单分子膜(包括1,2-双棕榈酰- san -甘油-3-磷酸胆碱)的相互作用,强调了癌变和健康细胞膜模型之间的行为差异(Wrobel et al., 2024)。

  • 胆固醇改变模型细胞膜的界面水排列。:该研究探讨了胆固醇如何影响包括1,2-双棕榈酰-sn-甘油-3-磷酸胆碱在内的模型细胞膜界面处的水排列,为膜生物物理学提供启示(Orlikowska-Rzeznik et al., 2024)。

  • 脂质组成对囊泡蛋白吸附的影响BSA案例研究。:研究了不同的脂质成分,包括1,2-双棕榈酰-sn-甘油-3-磷酸胆碱,对牛血清白蛋白在囊泡上吸附的影响,以了解蛋白质-脂质相互作用(Amarandi et al., 2024)。

  • 脂筏存在时布洛芬在模型膜中的空间排列。:本文研究了布洛芬在含有脂筏和1,2-双棕榈酰-sn-甘油-3-磷酸胆碱的模型膜内的排列,揭示了药物-膜相互作用(Kashnik et al., 2024)。

聯結

通过结晶纯化。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Johannes Thoma et al.
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
Edyta Paszko et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Fernando R Moya et al.
Pediatrics, 115(4), 1018-1029 (2005-04-05)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
John M Franck et al.
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause
Xu Hannah Zhang et al.
Journal of cell science, 120(Pt 23), 4134-4143 (2007-11-23)
The G1 phase of the cell cycle is marked by the rapid turnover of phospholipids. This turnover is regulated by CTP:phosphocholine-cytidylyltransferase (CCT) and group VIA Ca(2+)-independent-phospholipase A(2) (iPLA(2)). We previously reported that inhibition of iPLA(2) arrests cells in G1 phase

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