P4306

Platelet-Derived Growth Factor-BB 人

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 同義詞: PDGF-BB
• MDL號碼: MFCD00213023
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 產品名稱: Platelet-Derived Growth Factor-BB 人, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in E. coli
• 化驗: ≥97% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: 1.0-3.0 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: 24.3 kDa
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: ≤1 EU/μg
• UniProt登錄號: P01127
• 儲存溫度: −20°C
• 基因資訊: human ... PDGFB(5155)

描述

一般說明

Platelet-Derived Growth Factor (PDGF), a cationic polypeptide, is an important serum mitogen predominantly found in cells of mesenchymal origin. PDGF is mapped to human chromosome 7p22.3 and is expressed in smooth muscle cells, endothelial cells and macrophages. PDGF exists as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.

應用

Platelet-Derived Growth Factor-BB human has been used in induction of DNA synthesis and proliferation in low-concentration serum.

生化／生理作用

Platelet-derived growth factor (PDGF) is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF elicits multifunctional actions in a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. PDGF-BB isomer is highly expressed in tumor, mediating oncogenic pericyte recruitment and is is a key regulator of angiogenesis. PDGF-BB controls bone homeostasis, repair and regeneration. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins and modulates LDL receptor binding.

其他說明

Dimer of the B chain of human PDGF.

外觀

Lyophilized from a 0.2 μm filtered solution.

分析報告

The biological activity is measured by the dose-dependent stimulation of thymidine uptake in BALB/c 3T3 cells.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)