P3487

Monoclonal Anti-PTEN antibody produced in mouse

~1 mg/mL, purified immunoglobulin, clone PTN-18, buffered aqueous solution

• 同義詞: Anti-Mutated in multiple advanced cancers 1, Anti-PTEN1, Anti-PTENbeta, Anti-Phosphatase and tensin homolog, Anti-TEP1
• MDL號碼: MFCD02097285
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: PTN-18, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~55 kDa
• 物種活性: mouse, human, rat
• 濃度: ~1 mg/mL
• 技術: immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation; indirect ELISA: suitable; microarray: suitable; western blot: 5-10 μg/mL using whole extract of rat brain
• 同型: IgG2a
• UniProt登錄號: P60484
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PTEN(5728) ; mouse ... Pten(19211) ; rat ... Pten(50557)

描述

一般說明

The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.

特異性

The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.

免疫原

synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).

生化／生理作用

The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable