P302-05

Porcine Pulmonary Artery Endothelial Cells: PPAEC (Cryovial)

• 分類程式碼代碼: 41106514
• NACRES: NA.81

屬性

• 生物源: Porcine pulmonary artery (Normal healthy)
• 品質等級: 100
• 形狀: solid
• 包裝: pkg of 500,000 cells
• 製造商／商標名: Cell Applications, Inc
• 增長模式: Adherent
• 染色體組型: 2n = 38
• 形態學: Endothelial
• 技術: cell culture | mammalian: suitable
• 相關疾病: diabetes; cardiovascular diseases
• 運輸包裝: dry ice
• 儲存溫度: −196°C

描述

一般說明

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PPAEC have been used in a pioneer study of endothelial cell motility, where it was determined that asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide production and a cardiovascular risk factor, decreased PKG-mediated phosphorylation of VASP, leading to downregulation of Rac1 and induction of stress fibers and focal adhesions via RhoA/ROCK dependent mechanism, leading to decreased cell motility, and increase in endothelial permeability, thus linking vascular repair and function with NO production (Wojciak-Stothard, 2007, 2009). PPAEC were also used to assess endothelial adhesion to decellularized porcine arteries in order to develop grafts for human vascular repair (Xiong, 2013).

細胞系來源

Artery

應用

cardiovascular function, screening of drug candidates, angiogenesis, vasodilator function, transport of deoxygenated bloood from heart to lungs

成分

Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO

準備報告

• 1st passage, >500,000 cells in Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
• Can be cultured at least 16 doublings

例行更新培養

Please refer to the PPAEC Culture Protocol.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable