O3514

Osteopontin from bovine milk

lyophilized powder

• 同義詞: Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
• MDL號碼: MFCD03100698
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: bovine milk
• 品質等級: 100
• 無菌: sterile
• 形狀: lyophilized powder
• 分子量: ~60 kDa
• 包裝: pkg of 50 μg
• 技術: cell culture | mammalian: suitable
• UniProt登錄號: P31098; P31096
• 運輸包裝: ambient
• 儲存溫度: −20°C
• 基因資訊: cow ... SPP1(281499)

描述

一般說明

Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.

生化／生理作用

A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.

Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

分析報告

The biological activity is measured by its ability to mediate 293 cell adhesion.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)