N6538

Anti-NR4A2 antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR
• MDL號碼: MFCD02263849
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~70 kDa
• 物種活性: human
• 加強驗證: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1.5 mg/mL
• 技術: indirect immunofluorescence: 4-8 μg/mL using HEK-293T cell lysate expressing human NR4A2; western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2
• UniProt登錄號: P43354
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NR4A2(4929)

描述

一般說明

NR4A2 is encoded by the gene mapped to human chromosome 2q24.1.

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.

特異性

Anti-NR4A2 specifically recognizes human NR4A2.

應用

Anti-NR4A2 antibody produced in rabbit has also been used in immunohistochemistry (IHC).

Anti-NR4A2 antibody produced in rabbit has been used in western blotting.

生化／生理作用

Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.

Nuclear receptor subfamily 4 group A member 2 (NR4A2) receptors function as transcription factors. NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) in the form of monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, prostaglandins, growth factors, calcium, inflammatory cytokines, peptide hormones, and neurotransmitters in a cell type specific manner. Cyclic adenosine monophosphate (cAMP) triggers the hepatic expression of NR4A2 in response to glucagon and fasting. Diabetic mice with elevated gluconeogenesis also show high levels of NR4A2. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. Mice lacking Nurr1 failed to generate midbrain dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia and manic depression.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

儲存和穩定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)