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N6252

Sigma-Aldrich

去甲哈尔满

≥98% (TLC), crystalline, monoamine oxidase inhibitor

同義詞:

β-咔啉, 9H-吡啶并[3,4-b]吲哚

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About This Item

經驗公式（希爾表示法）:
C11H8N2
CAS號碼:
244-63-3
分子量：:
168.19
EC號碼:
205-959-0
MDL號碼:
MFCD00004956
分類程式碼代碼:
12352200
PubChem物質ID:
24897776
NACRES:
NA.77

產品名稱

去甲哈尔满, crystalline

形狀

crystalline

品質等級

200

顏色

light yellow

儲存溫度

2-8°C

SMILES 字串

c1ccc2c(c1)[nH]c3cnccc23

InChI

1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H

InChI 密鑰

AIFRHYZBTHREPW-UHFFFAOYSA-N

基因資訊

human ... IKBKB(3551)
rat ... Gabra2(29706)

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一般說明

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

應用

Norharmane has been used:
  • as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
  • as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
  • as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

生化／生理作用

吲哚胺 2,3-双加氧酶 (IDO) 的抑制剂。
Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
BCCH1190
BCCH0395
BCCF8482
BCCD5463
BCCC5353

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