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N4288

Sigma-Aldrich

Anti-NAV3 (C-terminal) 兔抗

enhanced validation

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~280 kDa

物種活性

human, mouse (predicted), rat (predicted)

包裝

antibody small pack of 25 μL

加強驗證

recombinant expression
Learn more about Antibody Enhanced Validation

濃度

~1 mg/mL

技術

western blot: 1-2 μg/mL using HEK-292T cells lysate expressing human NAV3 fusion protein

UniProt登錄號

Q8IVL0

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NAV3(89795)
mouse ... Nav3(260315)
rat ... Nav3(314814)

相關類別

一般說明

NAV3 belongs to the neuron navigator (NAV) family of proteins. NAV3 is expressed in adult heart, kidney, and brain.
Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.

應用

Anti-NAV3 (C-terminal) antibody has been used in immunoblotting, western blotting.

生化／生理作用

NAV3 has been suggested to function as a novel tumor suppressor gene. Deletions and translocation affecting NAV3 have been shown to occur in patients with advanced mycosis fungoides or Sézary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL).
Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

分析證明 (COA)

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Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue
Karenko Leena, et al.
Cancer Research, 65(18), 8101-8110 (2005)
Ryan Charles Pink et al.
Gynecologic oncology, 137(1), 143-151 (2015-01-13)
Ovarian cancer is the deadliest gynaecological cancer. A major contributor to the poor survival rate is the development of chemoresistance to platinum-based therapies such as cisplatin and carboplatin. Here we aimed to test the role of miRNAs in the acquisition
Hadas Cohen-Dvashi et al.
EMBO molecular medicine, 7(3), 299-314 (2015-02-14)
Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator-3 (NAV3), a gene frequently mutated or deleted in human tumors, as a regulator of epithelial migration and invasion. Following induction by growth factors, NAV3 localizes
E Carlsson et al.
British journal of cancer, 106(3), 517-524 (2011-12-17)
The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). We analysed changes in chromosome 12 and NAV3 copy number in
Pilvi Maliniemi et al.
Experimental dermatology, 20(11), 926-931 (2011-10-15)
The neuron navigator 3 (NAV3) gene on chromosome 12q21 encodes a microtubule plus end tracking protein and belongs to the navigator family of cytoskeletal regulators. Loss of heterozygosity on 12q has previously been suggested to be associated with poor prognosis
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