N0915

NSC43067

≥98% (HPLC)

• 同義詞: 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067
• 經驗公式（希爾表示法）: C₁₄H₁₂OS
• CAS號碼: 26903-26-4
• 分子量：: 228.31
• MDL號碼: MFCD00489751
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329818472
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: light yellow to light tan
• 溶解度: DMSO: >20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cc1ccc(s1)C(=O)\C=C\c2ccccc2
• InChI: 1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+
• InChI 密鑰: AOUMOFQEBZGSPD-CMDGGOBGSA-N

描述

生化／生理作用

NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

特點和優勢

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H413
• 防範說明: P264 - P270 - P273 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 4
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable