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Merck
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重要文件

N0632

Sigma-Aldrich

β-烟酰胺腺嘌呤二核苷酸 钠盐

同義詞:

DPN, NAD, β-DPN, β-NAD, 二磷酸吡啶核苷酸, 辅酶, 辅酶 1, 辅酶I

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About This Item

經驗公式(希爾表示法):
C21H26N7NaO14P2
CAS號碼:
分子量::
685.41
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

化驗

≥95% (HPLC)
≥95% (enzymatic)
≥95% (spectrophotometric assay)

品質等級

形狀

powder

儲存溫度

−20°C

SMILES 字串

[Na].NC(=O)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O

InChI

1S/C21H28N7O14P2.Na.H/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;

InChI 密鑰

GSZRXOXBGUIRAU-UHFFFAOYSA-N

基因資訊

生化/生理作用

β-烟酰胺腺嘌呤二核苷酸 (NAD+)和β-还原烟酰胺腺嘌呤二核苷酸(NADH)组成辅酶氧化还原对(NAD+:NADH),参与广泛的酶催化氧化还原反应。 另外,在氧化还原反应中,NAD+/NADH是ADP核糖化(ADP-核糖基转移酶;聚(ADP-核酸酶)聚合酶 )反应中的ADP-核酸酶单元供体。

其他說明

本品是普通型 NAD。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Irshad Ali et al.
PloS one, 15(9), e0239340-e0239340 (2020-09-18)
In this study, an enzymatic pathway has been developed to replicate the Calvin Cycle by creating the individual steps of the carbon cycle in a bioreactor. The technology known as "artificial photosynthesis" converts CO2 emissions into a variety of intermediates
Raquel Villanueva et al.
Antioxidants & redox signaling, 30(18), 2013-2029 (2018-11-20)
Aims: The human apoptosis-inducing factor (hAIF) supports OXPHOS biogenesis and programmed cell death, with missense mutations producing neurodegenerative phenotypes.
Lifeng Yang et al.
Cell metabolism, 31(4), 809-821 (2020-03-19)
NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with impaired electron transport chain activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH-producing pathways: glucose, glutamine, and fat oxidation.
Mikako Yagi et al.
The EMBO journal, 40(8), e105268-e105268 (2021-02-03)
Mitochondrial translation dysfunction is associated with neurodegenerative and cardiovascular diseases. Cells eliminate defective mitochondria by the lysosomal machinery via autophagy. The relationship between mitochondrial translation and lysosomal function is unknown. In this study, mitochondrial translation-deficient hearts from p32-knockout mice were
Carolina Ortiz-Cordero et al.
eLife, 10 (2021-01-30)
Mutations in the fukutin-related protein (FKRP) cause Walker-Warburg syndrome (WWS), a severe form of congenital muscular dystrophy. Here, we established a WWS human induced pluripotent stem cell-derived myogenic model that recapitulates hallmarks of WWS pathology. We used this model to

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