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Key Documents

M9695

Sigma-Aldrich

Matrix Metalloproteinase-12, Catalytic Domain 人

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution

同義詞:

MMP-12, Macrophage Elastase

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

重組細胞

expressed in E. coli

品質等級

化驗

≥95% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

分子量

calculated mol wt 20.3 kDa

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... MMP12(4321)

一般說明

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.

生化/生理作用

MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

單位定義

One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.

外觀

Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.

法律資訊

Brij is a registered trademark of Croda International PLC

危險聲明

防範說明

危險分類

Aquatic Chronic 3

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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The Journal of biological chemistry, 268(32), 23824-23829 (1993-11-15)
Human alveolar macrophages have the capacity to degrade elastin. As an approach to define proteinases responsible for this activity, we recently cloned a murine macrophage elastase cDNA and demonstrated that it is a member of the matrix metalloproteinase gene family
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Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar macrophages of cigarette smokers. To understand more about HME expression, analysis of the structure and location of

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