M7570

Anti-Mucolipin-3 (N-terminal) 兔抗

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-MCOLN3, Anti-MLN3, Anti-TRPML3
• 分類程式碼代碼: 12352203

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~75 kDa
• 物種活性: human
• 加強驗證: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1.5 mg/mL
• 技術: western blot: 0.25-0.5 μg/mL using HEK-293T cells expressing human mucolipin-3
• UniProt登錄號: Q8TDD5
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MCOLN3(55283) ; mouse ... Mcoln3(171166) ; rat ... Mcoln3(308022)

描述

一般說明

Mucolipin 3 (MCOLN3) belongs to the mucolipin family of ion channels and the superfamily of transient receptor potential (TRP) channels. This 553-amino acid protein is expressed in the early and late endosomes of epithelial cells. MCOLN3 possesses six transmembrane domains with the tails oriented towards the interior the cytosol.

Mucolipin-3 is mapped to human chromosome 1p22.3.

免疫原

synthetic peptide corresponding to amino acids 26-43 of human mucolipin-3. This sequence is identical between human and mouse and highly conserved in mouse and rat.

應用

Anti-Mucolipin-3 (N-terminal) antibody produced in rabbit
has been used in immunoblotting and immunostaining.

生化／生理作用

Mucolipin 3 (MCOLN3) is a Ca²⁺-permeable channel which regulates the cargo traffic along the endosomal pathway. Its activity is regulated by changes in the pH. Overexpression of MCOLN3 in cells lead to large variations in the endosomal pathway and the depletion in its levels leads to the degradation of the epidermal growth factor receptor (EGFR).

Mutations in mouse mucolipin3 (MLN3, TRPML3) encoded by the MCOLN3 gene, are associated with deafness and pigmentation defects in varitint-waddler mice.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°C）: Not applicable