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Merck
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重要文件

M5644

Sigma-Aldrich

(±)-甲氧基维拉帕米 盐酸盐

≥98%

同義詞:

(±)-α-[3-[(2-(3,4-二甲氧基苯基)乙基)甲氨基]丙基]-3,4,5-三甲氧基-α-(1-甲基乙基)苯乙腈 盐酸盐, D 600, 戈洛帕米

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About This Item

經驗公式(希爾表示法):
C28H40N2O5 · HCl
CAS號碼:
分子量::
521.09
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98%

SMILES 字串

Cl[H].COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC

InChI

1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H

InChI 密鑰

OKCRIUNHEQSXFD-UHFFFAOYSA-N

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相關類別

一般說明

甲氧维拉帕米是一种钙调素拮抗剂。通过调节钙信号控制鞭毛糖蛋白再分布。甲氧维拉帕米影响细胞内钙水平的影响,并影响精子获能功能。

應用

(±)-甲氧基维拉帕米盐酸盐已被用于:
  • 曼氏血吸虫 寄生虫
  • 中作为钙通道拮抗剂在培养的巨噬细胞中作为钙条目阻滞剂
  • 在 L 型电压门控 Ca 2 + 通道抑制

生化/生理作用

阻断 L 型 Ca2+ 通道

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Shigehiro Hayashi et al.
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Ho Jae Han et al.
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Embryonic stem (ES) cells are provided as a powerful tool for developmental biology and have been shown to respond to insulin. However, little is known about the effect of insulin on [Ca2+]i regulation in the ES cells, although many cellular
M A Bagni et al.
American journal of physiology. Cell physiology, 286(6), C1353-C1357 (2004-01-30)
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Anamika Awasthi et al.
Bioorganic & medicinal chemistry letters, 15(24), 5412-5415 (2005-10-11)
Ab initio Hartree-Fock calculations have been performed at the 6-31G level to study the pharmacophoric features of verapamil. Both the unprotonated and the protonated forms of verapamil have been studied. The study predicts that the drug enters the body in
Iliyana D Stefanova et al.
Molecular nutrition & food research, 51(4), 468-472 (2007-03-16)
Melanoidins obtained from L-arginine and D-glucose (MW > 3500 Da) were tested for their ability to influence the contractility of gastric smooth muscles. A study within the range 0.1-10 mg/mL revealed that at low concentrations, the melanoidins provoked concentration-dependent contraction

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