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重要文件

M3568

Sigma-Aldrich

MSX-3 水合物

≥98% (HPLC), solid

同義詞:

3,7-二氢-8-[(1E)-2-(3-甲氧基苯基)乙烯基]-7-甲基-3- [3-(膦酰氧基)丙基-1-(2-丙炔基)-1H-嘌呤-2,6-二酮 二钠盐 水合物

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About This Item

經驗公式(希爾表示法):
C21H21N4O7PNa2 · xH2O
CAS號碼:
分子量::
518.37 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

儲存條件

protect from light

顏色

pale yellow

溶解度

H2O: soluble >5 mg/mL at 60 °C

儲存溫度

−20°C

SMILES 字串

O.[Na+].[Na+].COc1cccc(\C=C\c2nc3N(CCCOP([O-])([O-])=O)C(=O)N(CC#C)C(=O)c3n2C)c1

InChI

1S/C21H23N4O7P.2Na.H2O/c1-4-11-25-20(26)18-19(24(21(25)27)12-6-13-32-33(28,29)30)22-17(23(18)2)10-9-15-7-5-8-16(14-15)31-3;;;/h1,5,7-10,14H,6,11-13H2,2-3H3,(H2,28,29,30);;;1H2/q;2*+1;/p-2/b10-9+;;;

InChI 密鑰

FANGYFUIIWHEAQ-WCVSPGPUSA-L

一般說明

Soluble with gradual warming to temperature for 10 minutes. Solution might appear slightly unclear when it is freshly made.

生化/生理作用

选择性 A2A 腺苷受体拮抗剂前药。

注意

光敏和气敏

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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Monique A Spillman et al.
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Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed preexisting disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperitoneal
W Hauber et al.
Neuroreport, 9(8), 1803-1806 (1998-07-17)
Motor effects mediated through adenosine A2A receptors within the caudate-putamen were investigated in rats using bilateral microinfusions of MSX-3 (9 microg in 1 microl per side), a water-soluble phosphate prodrug of the selective A2A receptor antagonist MSX-2. Blockade of striatal
R Sauer et al.
Journal of medicinal chemistry, 43(3), 440-448 (2000-02-12)
Water-soluble prodrugs of potent, A(2A)-selective adenosine receptor (AR) antagonists were prepared. 8-(m-Bromostyryl)-3, 7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the analogous 8-(m-methoxystyryl)xanthine derivative (MS-DMPX, 5b) were used as starting points. It was found that polar functional groups suitable for the attachment of a

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