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Key Documents

M266

Sigma-Aldrich

抗-谷氨酸受体NMDAR2C(NR2C) 兔抗

affinity isolated antibody, lyophilized powder

同義詞:

Anti-GluN2C, Anti-NMDAR2C, Anti-NR2C

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

lyophilized powder

分子量

antigen 140 kDa (NR2C subunit)
antigen 180 kDa (NR2A and NR2B bands)

物種活性

rat, human, mouse

技術

immunohistochemistry (frozen sections): 1:1000
immunoprecipitation (IP): 3 μL using 200 μg of rat cerebellum.
indirect immunofluorescence: 1:1000 using frozen sections
western blot: 1:1000 using 200 μg cell lysate

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... GRIN2C(2905)
mouse ... Grin2c(14813)
rat ... Grin2c(24411)

免疫原

NR2C的C末端部分(25-130位氨基酸)。

外觀

从碳酸氢铵(5 mM)冻干。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Luke A Esposito
Methods in molecular biology (Clifton, N.J.), 670, 71-84 (2010-10-23)
The accumulation of the amyloid-β (Aβ) peptide in the form of insoluble fibrillar deposits and soluble oligomeric aggregates is widely believed to play a causal role in Alzheimer's disease (AD). Proteolytic cleavage of APP by the β-site APP cleaving enzyme
Michele Buddle et al.
Brain research, 978(1-2), 38-50 (2003-07-02)
MAP2 (microtubule-associated protein 2) is a cytoskeletal phosphoprotein that regulates the dynamic assembly characteristics of microtubules and appears to provide scaffolding for organelle distribution into the dendrites and for the localization of signal transduction apparatus in dendrites, particularly near spines.
Stéphane Peineau et al.
Methods in molecular biology (Clifton, N.J.), 1677, 253-263 (2017-10-08)
Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The
K K Yung
Neuroreport, 9(7), 1639-1644 (1998-06-19)
Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A-C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR1 alpha was detected in laminae I-III of the dorsal horn, whilst mGluR2/3
H Monyer et al.
Science (New York, N.Y.), 256(5060), 1217-1221 (1992-05-22)
The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A

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