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重要文件

L0906

Sigma-Aldrich

L-α-溶血卵磷脂 来源于大豆

≥99%, lyophilized powder

同義詞:

1-酰基-sn-甘油-3-磷酸胆碱, L-α-Lysolecithin

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About This Item

CAS號碼:
EC號碼:
MDL號碼:
分類程式碼代碼:
51321705
NACRES:
NA.25

生物源

soybean

品質等級

描述

zwitterionic

化驗

≥99%

形狀

lyophilized powder

官能基

phospholipid

脂質類型

phosphoglycerides

運輸包裝

ambient

儲存溫度

−20°C

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生化/生理作用

溶血卵磷脂为氧化型低密度脂蛋白的主要成分,并且与多种炎症反应包括动脉粥样硬化有关。用于使脊髓神经元脱髓鞘以及研究作为髓鞘再生基础的过程。它可激活蛋白激酶 C、p38 MAP 激酶、p42 MAP 激酶和 jun 激酶 (JNK) 途径,以及激活 c-jun 的转录。
溶血卵磷脂为氧化型低密度脂蛋白的主要成分,并且与多种炎症反应包括动脉粥样硬化有关。用于使脊髓神经元脱髓鞘以及研究作为髓鞘再生基础的过程。它可激活蛋白激酶 C、p38 MAP 激酶、p42 MAP 激酶和 jun 激酶 (JNK) 途径,以及激活 c-jun 的转录。溶血卵磷脂在心肌缺血过程中积累并可能通过对细胞间隙连接通讯的解偶联诱发心率失常,以及通过提高心肌细胞的 Na+ 负荷增加缺血性损伤。它还可激活 TREK1、TREK2 和 TRAAK K+ 通道。

包裝

在氩气下包装。

準備報告

通过磷脂酶 A 作用于大豆 L-α-磷脂酰胆碱 (P 6263) 制得。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Guillaume Bach et al.
Clinical and vaccine immunology : CVI, 17(3), 429-438 (2010-01-15)
Improving vaccine immunogenicity by developing new adjuvant formulations has long been a goal of vaccinologists. It has previously been shown that a natural mix of lysophosphatidylcholine (LPC) from chicken eggs promotes mature dendritic cell (DC) generation in vitro and primes
E de Lamirande et al.
Journal of andrology, 33(5), 1025-1035 (2012-03-10)
Capacitation (CAP) and acrosome reaction (AR) are sequential processes of sperm activation. Beside the known ionic, membrane, and transduction events and final release of proteolytic enzymes that help sperm movement toward the egg, chromatin changes, such as a physiological remodeling
Oliver Murch et al.
British journal of pharmacology, 148(6), 769-777 (2006-06-06)
1. Lysophosphatidylcholine (LPC) modulates the inflammatory response and reduces mortality in animal models of sepsis. Here, we investigate the effects of LPC from synthetic (sLPC) and natural, soy bean derived LPC, (nLPC) sources on the organ injury/dysfunction caused by systemic
Hui-Ching Tseng et al.
Cellular and molecular life sciences : CMLS, 75(24), 4599-4617 (2018-09-20)
Lysophosphatidylcholine (LysoPC) has been shown to induce the expression of inflammatory proteins, including cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6), associated with cardiac fibrosis. Here, we demonstrated that LysoPC-induced COX-2 and IL-6 expression was inhibited by silencing NADPH oxidase 1, 2, 4
Hui-Ching Tseng et al.
Journal of lipid research, 60(9), 1573-1589 (2019-08-01)
Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation. Here, we evaluated the mechanisms underlying LPC-mediated collagen induction via mitochondrial events in human cardiac fibroblasts (HCFs), coupling application of

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