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Merck
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Key Documents

K4894

Sigma-Aldrich

Kolliphor HS 188

solid

同義詞:

聚(乙二醇)- 嵌段 - 聚(丙二醇)- 嵌段 - 聚(乙二醇), Lutrol F68, Poloxamer 188

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12161902
NACRES:
NA.75

agency

USP/NF
meets USP testing specifications

品質等級

形狀

solid

分子量

8.400 g/mol

pH值

5.0-7.5(2.5% solution)

應用

sample preservation

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI 密鑰

RVGRUAULSDPKGF-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

Poloxamer 188是一种非离子型两亲共聚物,其中心链为疏水聚氧丙烯,末端为亲水聚氧乙烯。

應用

Poloxamer 188已用作细胞解离/最小基本介质(MEM)的组分,以使用 EpCAM 抗体偶联磁珠分选肿瘤细胞。
Poloxamer 188已被用作F17培养基中的补充剂,用于培养HEK293-6E细胞。它还被用作流式细胞分析(FACS)缓冲液的组分,用作保护细胞免受流体动力损害的非离子型除垢剂。

生化/生理作用

Poloxamer 188具有细胞保护、血液流变学、抗炎、抗血栓活性。它可以维持膜屏障功能的稳定。P188 可降低表面张力和疏水细胞粘附。它还能抑制受 Fe2+ 和 H2O2 刺激的脂质过氧化。

法律資訊

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1


分析證明 (COA)

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Christian Margretter
Journal of Molecular Recognition (2016)
S Dhara et al.
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Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Denise Chroscinski
eLife (2015)
S Dhara et al.
Nature communications, 12(1), 3044-3044 (2021-05-26)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
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