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重要文件

K2015

Sigma-Aldrich

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

同義詞:

SF 2370

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About This Item

經驗公式(希爾表示法):
C27H21N3O5
CAS號碼:
分子量::
467.47
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

Nonomuraea longicatena

品質等級

化驗

>98%

形狀

solution

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI 密鑰

KOZFSFOOLUUIGY-SOLYNIJKSA-N

基因資訊

human ... NTRK1(4914)
rat ... Prkca(24680)

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生化/生理作用

K-252a 还是Trk(酪氨酸激酶)受体的特异性抑制剂,可选择性阻断神经生长因子的效应。较低浓度的 K-252a 可作为神经保护性化合物,促进原代神经元培养物存活。K-252a 通过抑制 Cdc2 和 Cdc25c,诱导细胞周期停滞和凋亡。K-252a 可改善 SCID 小鼠-人类皮肤模型中的牛皮癣状况,并可抑制与急性胰腺炎相关的机械超敏反应和神经肽上调。

特點和優勢

《受体分类和信号转导》手册的 MetPKC 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

外觀

以 0.2μm 过滤的 1 mM 二甲亚砜 (DMSO) 溶液形式提供。

相關產品

產品號碼
描述
訂價

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

188.6 °F - closed cup

閃點(°C)

87 °C - closed cup

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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分析證明 (COA)

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Siba P Raychaudhuri et al.
The Journal of investigative dermatology, 122(3), 812-819 (2004-04-17)
The peripheral nervous system, in addition to its sensory and motor functions, can induce a local inflammatory response known as neurogenic inflammation. This phenomenon plays a critical role in several inflammatory diseases, e.g., asthma, atopy, rheumatoid arthritis, psoriasis, and ulcerative
Ruslana Bryk et al.
Bioorganic & medicinal chemistry letters, 21(13), 4108-4114 (2011-06-03)
We report the identification of new, structurally diverse inhibitors of interferon-induced, double-stranded RNA-activated protein kinase (PKR) using a combined experimental and computational approach. A training set with which to build a predictive statistical model was generated by screening a set
Z Pawlowska et al.
Journal of neurochemistry, 60(2), 678-686 (1993-02-01)
The phosphorylation of surface proteins by ecto-protein kinase has been proposed to play a role in mechanisms underlying neuronal differentiation and their responsiveness to nerve growth factor (NGF). PC12 clones represent an optimal model for investigating the mode of action
Winston, J.H., et al.
Pain, 4, 329-337 (2003)
M A Glicksman et al.
Journal of neurochemistry, 64(4), 1502-1512 (1995-04-01)
The organic molecule K-252a promoted cell survival, neurite outgrowth, and increased choline acetyltransferase (ChAT) activity in rat embryonic striatal and basal forebrain cultures in a concentration-dependent manner. A two- to threefold increase in survival was observed at 75 nM K-252a

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