K0890

Anti-Potassium Channel K_V11.3 (erg3) 兔抗

affinity isolated antibody, lyophilized powder

• 同義詞: Anti-KCNH7, Anti-ether-a-go-go-related channel 3
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: mouse, human, rat
• 技術: immunohistochemistry: suitable using rat brain sections; western blot: 1:300 using rat brain lysates
• UniProt登錄號: Q9NS40
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KCNH7(90134) ; mouse ... Kcnh7(170738) ; rat ... Kcnh7(170739)

描述

一般說明

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K⁺ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.

特異性

The K_V11.3 antibody is directed against an intracellular epitope of C-terminal part of K_V11.3.

免疫原

synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat K_V11.3.

生化／生理作用

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K⁺ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.

外觀

Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.

重構

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

安全資訊

• 儲存類別代碼: 10 - Combustible liquids