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Merck
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重要文件

I8283

Sigma-Aldrich

ICI 63,197

≥98% (HPLC)

同義詞:

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

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About This Item

經驗公式(希爾表示法):
C9H13N5O
CAS號碼:
分子量::
207.23
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white

mp

161.8-163 °C

溶解度

DMSO: 13 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCCN1C(=O)C(C)=Cn2nc(N)nc12

InChI

1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

InChI 密鑰

UQDVRVNMIJAGRK-UHFFFAOYSA-N

生化/生理作用

Phosphodiesterase IV (PDE 4) inhibitor

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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T Hermsdorf et al.
Cellular signalling, 10(9), 629-635 (1998-10-30)
Primary cultures of rat hepatocytes were used to study the combined effects of insulin and dexamethasone on cyclic AMP phosphodiesterase 3 (PDE 3) and glycogen metabolism. PDE activity was measured in extracts obtained by hypotonic shock treatment of the particulate
A Bobik et al.
Journal of cardiovascular pharmacology, 6(5), 795-801 (1984-09-01)
We examined the effects of prolonged exposure of cardiac cells in primary culture to the partial beta-adrenoceptor agonist prenalterol and inhibitors of phosphodiesterase on their subsequent ability to increase intracellular cyclic AMP during a 5-min exposure to 50 microM isoprenaline
C B Archer et al.
The British journal of dermatology, 109(5), 559-564 (1983-11-01)
Peripheral blood lymphocyte cyclic AMP responses to isoprenaline, prostaglandin E2 and histamine were examined in patients with atopic eczema, in the presence and absence of a potent phosphodiesterase inhibitor (PDEI). Basal cyclic AMP levels were not significantly different in atopic
H Wachtel
Psychopharmacology, 77(4), 309-316 (1982-01-01)
The significance of a characteristic symptomatology (hypothermia, hypoactivity, forepaw shaking, grooming, head twitches) as a potential in vivo correlate of enhanced availability of brain adenosine cyclic 3',5'-monophosphate (cAMP) was examined in rats following systemic administration of various doses of dibutyryladenosine
H O Collier et al.
Federation proceedings, 40(5), 1513-1518 (1981-04-01)
A quasi-morphine withdrawal syndrome (QMWS) is a pattern of behavior closely resembling the true withdrawal syndrome in the opiate-dependent animal, which can be elicited acutely by a nonopiate drug in an opiate-naive animal. The main criteria proposed for the QMWS

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