生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
409405, monoclonal
形狀
lyophilized powder
物種活性
human
技術
western blot: 1-2 μg/mL
同型
IgG2b
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... IL1A(3552)
一般說明
Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. The IL-1α precursor produced initially is cleaved by calpain to produce a 16 kDa propeptide and 17 kDa mature protein. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The propeptide has nuclear localization sequence that enables it to shuttle to nucleus and activate transcription of target genes. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation.Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Monoclonal Anti-Interleukin-1a propeptide recognizes human Interleukin-1α propeptide. It does not cross-react with mature forms of mouse IL-1α or rabbit IL-1α.
Monoclonal Anti-Interleukin-1a propeptide recognizes human Interleukin-1α propeptide. It does not cross-react with mature forms of mouse IL-1α or rabbit IL-1α.
免疫原
purified, E. coli-derived recombinant human interleukin-1α propeptide (aa 1-112).
應用
Anti-interleukin 1α antibody is suitable for immunoblotting at a working concentration of 1-2 μg/ml.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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相關產品
產品號碼
描述
訂價
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Interleukin-1, inflammasomes, autoinflammation and the skin
Contassot E et al
Swiss Medical Weekly, 142, w13590-w13590 (2010)
Interleukin-1 (IL-1) pathway
Weber A et al
Science Signaling, 3, p-p (2010)
S Z Ben-Sasson et al.
Cytokine, 56(1), 122-125 (2011-08-17)
IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct
J Novak et al.
Scientific reports, 10(1), 6995-6995 (2020-04-26)
Interleukin-1α (IL-1α) is a dual-function proinflammatory mediator. In addition to its role in the canonical IL-1 signaling pathway, which employs membrane-bound receptors, a growing body of evidence shows that IL-1α has some additional intracellular functions. We identified the interaction of
Charles A Dinarello
Current opinion in pharmacology, 4(4), 378-385 (2004-07-15)
All biological agents currently used for reducing TNFalpha activity in disease are neutralization strategies; however, there are several strategies for reducing interleukin (IL)-1 activities: the IL-1 receptor antagonist (IL-1Ra), anti-IL-1beta monoclonal antibodies, the IL-1 Trap, IL-1 receptor type I antibodies
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