推薦產品
起源
Sanofi Aventis
儲存溫度
2-8°C
SMILES 字串
CS(O)(=O)=O.CCC(NC(C)C)C(O)c1ccc(O)c(O)c1
InChI
1S/C13H21NO3.CH4O3S/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9;1-5(2,3)4/h5-8,10,13-17H,4H2,1-3H3;1H3,(H,2,3,4)
InChI 密鑰
SOYAGMVKMXZVNZ-UHFFFAOYSA-N
基因資訊
human ... ADRB1(153) , ADRB2(154) , ADRB3(155)
應用
Isoetharine mesylate salt has been used:
- as an adrenergic drug to test its effect on embryo implantation in 4-day pregnant mice
- as a substrate for recombinant human sulfotransferase (SULT) in SULT assay to monitor conjugation reaction
- as a β-2 agonist in collision-induced dissociation (CID) mass spectrometry analysis
生化／生理作用
Isoetharine is an agonist for β-adrenergic receptors and is a bronchodilator. It is a catecholic drug metabolized by sulfotransferases and is present in human urine and plasma as a sulfated metabolite. Catechol O-methyltransferase (COMT) also mediates the methylation of isoetharine in the metabolic conjugation pathway.
特點和優勢
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
N B Charan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 82(2), 686-692 (1997-02-01)
In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 x 10(-2) M concentration).
Aronson JK
- Pesticide Residues in Food - 1992:
Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Rome, 21-30 September 1992
(2016)
P Carvalho et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(1), 215-221 (1998-02-06)
We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5
Gas-phase dissociation pathways of Beta-2 agonists
Carlo MJ, et al.
International Journal of Mass Spectrometry, 463, 116548-116548 (2021)
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