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Merck
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重要文件

I2786

Sigma-Aldrich

IL-6 human

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

同義詞:

Interleukin-6 human, B cell stimulating factor (BSF-2), IL-6, IL6, hepatocyte stimulating factor (HSF), interferon b2 (IFNb2), interleukin hybridoma/plasmacytoma-1 (IL-HP1), monocyte derived human B cell growth factor, plasmacytoma growth factor (PCT-GF)

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

產品名稱

Interleukin-6 human, IL-6, recombinant, expressed in E. coli, Carrier Free

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

>97% (SDS-PAGE)

形狀

lyophilized powder

效力

0.2-2.0 ng/mL Biological Activity EC50

品質

Carrier Free

分子量

26 kDa

包裝

pkg of 10 μg

儲存條件

avoid repeated freeze/thaw cycles

雜質

≤1 EU/μg protein Endotoxin Level

顏色

white

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... IL6(3569)

一般說明

Interleukin-6 (IL-6) is a multi-functional 26 kDa protein originally discovered in the medium of RNA-stimulated fibroblastoid cells1. IL-6 appears to be directly
involved in the immune responses that occur after infection and cellular injury, and it may prove to be as important as IL-1 and TNF-a in regulating the acute phase response2,3.

IL-6 is reportedly produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells, and hepatocytes. IL-6 induces multiple effects as indicated by its numerous synonyms4. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes5. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors6.This product is lyophilized from a 0.2 mm-filtered solution of phosphate buffered saline, pH 7.4, containing a stabilizer.

The product was prepared from raw materials verified to be carrier free.

應用

Human interleukin-6 (IL-6) has been used to study the effects of IL-6, along with IL-8 and IL-1β, on the clot structure of healthy blood.

生化/生理作用

IL-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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