推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunohistochemistry: 1:20- 1:50
免疫原序列
RHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKT
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HSD3B1(3283)
一般說明
3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) is a key enzyme essential for the formation of steroid sex hormones. It is majorly expressed in mammary glands, prostate, placenta and sebaceous glands of skin. HSD3B1 gene is mapped to human chromosome 1p12 and has four exons.
免疫原
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
3 β-hydroxysteroid dehydrogenase/delta 5->4-isomerase type 1 (HSD3B1) catalyses the conversion of steroid dehydroepiandrosterone sulfate to estrogen precursors hormones. It regulates levels of dihydrotestosterone (DHT). HSD3B1 is highly expressed in breast cancer and HSD3B1 gene knockdown results in tumor growth inhibition. A single nucleotide polymorphism in the HSD3B1 gene enhances enzyme activity and improves dihydrotestosterone (DHT) production in castration-resistant prostate cancer (CRPC). Expression of HSD3B1 is downregulated in ovarian cancer. Polymorphism in HSD3B1 is implicated in individuals with hypertension.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST82530
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Hormones and the Endocrine System, 191-236 (2016)
Metabolism of dihydrotestosterone in human liver: importance of 3alpha-and 3beta hydroxysteroid dehydrogenase
Pirog EC and Collins DC
The Journal of Clinical Endocrinology and Metabolism, 84(9), 3217-3221 (1999)
Polymorphism in exon 4 of the human 3beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
Rosmond R, et al.
Biochemical and Biophysical Research Communications, 293(1), 629-632 (2002)
Identification of underexpressed genes in early-and late-stage primary ovarian tumors by suppression subtraction hybridization
Shridhar V, et al.
Cancer Research, 62(1), 262-270 (2002)
Variant allele of HSD3B1 increases progression to castration-resistant prostate cancer
Wu G, et al.
Prostate, 75(7), 777-782 (2015)
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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