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Merck
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Key Documents

HPA027774

Sigma-Aldrich

Anti-SLPI antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

同義詞:

Anti-ALK1, Anti-ALP, Anti-BLPI, Anti-HUSI, Anti-HUSI-I, Anti-WAP4, Anti-WFDC4, Anti-secretory leukocyte peptidase inhibitor

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

加強驗證

recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:500-1:1000

免疫原序列

SGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCV

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SLPI(6590)

一般說明

Secretory leukocyte peptidase inhibitor (SLPI) is a serine-protease inhibitor which belongs to whey acidic protein family. The gene is mapped to human chromosome 20q13.12. It has four exons and encodes protein of molecular weight 11.7 kDa. It has whey-acidic-protein (WAP) motifs and the cysteine disulfide bond is crucial for its compact structure. It is secreted by epithelial cells and is present in saliva, cervical mucus and in seminal fluid.

免疫原

secretory leukocyte peptidase inhibitor recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

Secretory leukocyte peptidase inhibitor (SLPI) functions to protect tissues during inflammation. It inhibits human immunodeficiency virus 1 (HIV-1) infection by interacting with and modulating cluster of differentiation (CD4) lymphocytes. SLPI has antimicrobial property and regulates wound healing. It also interacts with β1 tubulin in platelets and regulates proteolysis. SLPI promotes carcinogenesis in lung cancer. Low expression of SLPI in nasopharyngeal epithelium promotes Epstein-Barr virus (EBV)-mediated nasopharyngeal carcinoma (NPC). SLPI is highly expressed in ovarian and pancreatic cancer.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST86545

外觀

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells
Devoogdt N, et al.
Proceedings of the National Academy of Sciences of the USA, 100(10), 5778-5782 (2003)
Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappa pathway and is associated with poor overall survival
Clauss A, et al.
Neoplasia, 12(2), IN14-IN15 (2010)
Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
Ashcroft GS, et al.
Nature Medicine, 6(10), 1147-1153 (2000)
The relationship between secretory leukocyte protease inhibitor expression and Epstein-Barr virus status among patients with nasopharyngeal carcinoma
Tse KP, et al.
Anticancer Research, 32(4), 1299-1307 (2012)
Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
Schulze H, et al.
Blood, 104(13), 3949-3957 (2004)

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