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Key Documents

HPA004832

Sigma-Aldrich

抗-ARPC1B 兔抗

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

同義詞:

抗-Arp2/3复合体41 kDa亚基, 抗-p41-ARC, 抗-肌动蛋白相关蛋白2/3复合体亚基1B

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About This Item

分類程式碼代碼:
12352203
人類蛋白質圖譜編號:

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human, mouse, rat

加強驗證

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:200-1:500

免疫原序列

TVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESA

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... ARPC1B(10095)

一般說明

Arp2/3复合体由7个亚单位组成,包括Arp2、Arp3、p41-Arc、p34-Arc、p21-Arc、p20-Arc和p16-Arc(p复合体)。其中,ARPC1B是WD(色氨酸和天冬氨酸)重复蛋白Sop2家族的新成员。

免疫原

肌动蛋白相关蛋白2/3复合体亚基1B重组蛋白抗原表位标签(PrEST)

應用

成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质印迹(1篇论文)

生化/生理作用

ARPC1B(肌动蛋白相关蛋白2/3复合体,亚单位1B,41kDa)参与细胞皮层肌动蛋白纤维网络的形成。该蛋白亚基(ARPC1B)可维持Arp2/3复合体的结构和活性。p41-Arc是Arp2/3复合体的调控组分,其过表达会导致肌动蛋白纤维变化,使肌动蛋白在细胞核中积聚。这一变化进而会诱发内在抗肿瘤的过早衰老程序。

特點和優勢

Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。

每种Prestige 抗体的检测方法如下:
  • 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
  • 364个人重组蛋白片段的蛋白阵列。

聯結

Corresponding Antigen APREST86831

外觀

磷酸盐缓冲盐水溶液,pH 7.2,含有40%甘油和0.02%叠氮化钠

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Annabelle G Small et al.
Frontiers in immunology, 13, 840510-840510 (2022-03-24)
The phagocytosis-promoting complement receptor, Complement Receptor Immunoglobulin (CRIg), is exclusively expressed on macrophages. It has been demonstrated that expression in macrophages could be modulated by inflammatory mediators, including cytokines. This raised the possibility that a major phagocyte, the neutrophil, may
Thomas Hubert et al.
Biochemical and biophysical research communications, 404(1), 153-158 (2010-11-27)
Although many actin binding proteins such as cortactin and the Arp2/3 activator WASH localize at the centrosome, the presence and conformation of actin at the centrosome has remained elusive. Here, we report the localization of actin at the centrosome in
Walter H A Kahr et al.
Nature communications, 8, 14816-14816 (2017-04-04)
Human actin-related protein 2/3 complex (Arp2/3), required for actin filament branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in blood cells. Here we show in a child with microthrombocytopenia, eosinophilia and inflammatory disease, a homozygous frameshift mutation in
Larissa S Moniz et al.
Scientific reports, 7, 39985-39985 (2017-01-07)
To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3caH1047R) and deletion of Pten. Using mouse embryonic fibroblast (MEF) models
Dawei Wang et al.
eLife, 10 (2021-11-20)
Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits. However

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