H8041

Interleukin-23 human

IL-23, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture

• 同義詞: Human IL-23, IL-23 Cytokine, Interleukin 23
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in HEK 293 cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: ≤2 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: dimer 55 kDa (glycosylated)
• 包裝: pkg of 5X10 μg; pkg of 10 μg; pkg of 5 μg
• 技術: cell culture | mammalian: suitable
• 雜質: ≤1EU/mg
• UniProt登錄號: Q9NPF7
• 儲存溫度: −20°C
• 基因資訊: human ... IL23A(51561)

描述

一般說明

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

生化／生理作用

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

分析報告

The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.

法律資訊

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1