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H4884

Sigma-Aldrich

Hippuryl-His-Leu acetate salt

同義詞:

N-Benzoyl-Gly-His-Leu

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About This Item

經驗公式（希爾表示法）:
C21H27N5O5
CAS號碼:
103404-54-2
分子量：:
429.47
分類程式碼代碼:
12352200
PubChem物質ID:
329815212
NACRES:
NA.32

化驗

≥98% (HPLC)

品質等級

200

形狀

powder

溶解度

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

儲存溫度

−20°C

SMILES 字串

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.C2H4O2/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;1-2(3)4/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H3,(H,3,4)/t16-,17-;/m0./s1

InChI 密鑰

NSEVQQKNHZCIKL-QJHJCNPRSA-N

基因資訊

human ... ACE(1636) , ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421) , ACE2(70008) , ACE3(498012)

Amino Acid Sequence

NBz-Gly-His-Leu

生化／生理作用

血管紧张素转换酶底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin. The inhibition by flavan-3-ols and procyanidins was competitive
Neha Chaudhary et al.
Journal of food science and technology, 57(4), 1371-1381 (2020-03-18)
Controlled release of Emblicanin rich water soluble extract of Emblica officinalis (EEO) from the inner phase of water-in-oil-in-water type double emulsion (DE), during in vitro digestion and phagocytosis was investigated. It was observed that release of EEO (measured as total polyphenols
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The Journal of biological chemistry, 280(45), 37644-37650 (2005-09-13)
Human genetic data have associated angiotensin-converting enzyme (ACE) with Alzheimer disease (AD), and purified ACE has been reported to cleave synthetic amyloid beta-protein (Abeta) in vitro. Whether deficiency in ACE activity, arising from genetic alteration or pharmacological inhibition, can decrease
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Mammalian genome : official journal of the International Mammalian Genome Society, 20(3), 170-179 (2009-03-04)
In humans, the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene accounts for half of the variance in plasma ACE activity. The deletion allele is associated with high plasma ACE activity, cardiovascular disease, and renal disease. In rat, a
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