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Key Documents

H4516

Sigma-Aldrich

Hydrocodone (+)-bitartrate salt

同義詞:

4,5-Epoxy-3-methoxy-17-methyl-5α-morphinan-6-one (2R,3R)-2,3-dihydroxybutanedioate (1:1)

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About This Item

經驗公式(希爾表示法):
C18H21NO3 · C4H6O6
CAS號碼:
分子量::
449.45
EC號碼:
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

品質等級

藥物控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技術

HPLC: suitable
gas chromatography (GC): suitable

溶解度

H2O: 62 mg/mL
ethanol: soluble

應用

forensics and toxicology
veterinary

起源

Abbott

SMILES 字串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@]12CCC(=O)[C@]3([H])Oc4c(OC)ccc5C[C@H]1N(C)CC[C@@]23c45

InChI

1S/C18H21NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,17-,18-;1-,2-/m01/s1

InChI 密鑰

OJHZNMVJJKMFGX-BWCYBWMMSA-N

生化/生理作用

μ opioid receptor agonist; narcotic analgesic and antitussive.

特點和優勢

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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C J Kotzer et al.
The Journal of pharmacology and experimental therapeutics, 292(2), 803-809 (2000-01-20)
In this study, the activity of the delta-opioid receptor subtype-selective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selective agonists of the delta-opioid receptor (SB 227122), mu-opioid receptor (codeine and hydrocodone)
Z R Chen et al.
Life sciences, 48(22), 2165-2171 (1991-01-01)
The binding affinity to the mu receptor of some opioids chemically related to morphine and some of their metabolites was examined in rat brain homogenates with 3H-DAMGO. The chemical group at position 6 of the molecule had little effect on
D M Tomkins et al.
The Journal of pharmacology and experimental therapeutics, 280(3), 1374-1382 (1997-03-01)
Humans that lack cytochrome P450 2D6 (CYP2D6) activity may have an altered risk of drug dependence or abuse because this enzyme is important in the metabolism of some drugs of abuse, including hydrocodone. In rats, hydrocodone conversion to hydromorphone is

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