H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

≥98% (HPLC), solid

• 同義詞: (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
• 經驗公式（希爾表示法）: C₁₆H₂₅NO · HBr
• CAS號碼: 78095-19-9
• 分子量：: 328.29
• MDL號碼: MFCD00153810
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278480
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 光學活性: [α]25/D +68.2°, c = 1 in methanol(lit.)
• 儲存條件: desiccated; protect from light
• 顏色: white to off-white
• 溶解度: H₂O: >10 mg/mL at ±60 °C (with sonication)
• SMILES 字串: Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
• InChI: 1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1
• InChI 密鑰: BATPBOZTBNNDLN-PFEQFJNWSA-N
• 基因資訊: human ... HTR1A(3350)

描述

應用

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:

• in mice to test the activity of the serotonin receptor
• to test its effect on zebrafish melanocyte migration and survival
• to stimulate hippocampal neurons

生化／生理作用

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT_1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)