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應用
Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research .
生化／生理作用
Hck is a member of the Src tyrosine kinase family. Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia .
單位定義
One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30 °C at pH 7.4.
外觀
Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT
儲存類別代碼
10 - Combustible liquids
J M Lionberger et al.
The Journal of biological chemistry, 275(24), 18581-18585 (2000-06-13)
Bcr-Abl is the constitutively active protein-tyrosine kinase expressed as a result of the Philadelphia translocation in chronic myelogenous leukemia. Bcr-Abl is coupled to many of the same signaling pathways normally regulated by hematopoietic cytokines. Recent work shows that Hck, a
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