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生物源
chicken
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
製造商／商標名
Genway 15-288-20088F
技術
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HSD11B1(3290)
免疫原
HDL human native protein.
應用
Anti-HDL antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in metabolic tissues that include liver, adipose tissue and the central nervous system. It may contribute to the loss of muscle strength with age and is a key component of sarcopenia. Inhibition of HDL gene may have some therapeutic potential in sarcopenia. HDL gene variation may affect the physiological cortisol levels and the severity of age-related osteoporosis. It is involved in regenerating active glucocorticoids, that are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both associated with chronic low-grade inflammation. HDL acts as an oxidoreductase to yield active glucocorticoids, cortisol or corticosterone. It is expressed in normal human epidermal keratinocytes (NHEKs) and negatively regulates proliferation of NHEKs.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jirong Wang et al.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 22(6), 523-528 (2013-09-26)
Glucocorticoid hormones have been reported to contribute to the regulation of cellular proliferation and differentiation and to inhibit the growth of cells in several colon tumors and adenocarcinoma cell lines. As a regulator of glucocorticoid levels, type I isoform HSD11B1
Alixe H M Kilgour et al.
PloS one, 8(12), e84057-e84057 (2014-01-07)
Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute
Heide Siggelkow et al.
The Journal of clinical endocrinology and metabolism, 99(2), E293-E302 (2013-11-29)
Higher physiological cortisol levels may increase the risk of age-related osteoporosis. We hypothesized that common polymorphisms in the cortisol synthesis enzyme 11β-hydroxysteroid dehydrogenase (HSD11B) may cause interindividual variations in cortisol levels and age-related bone loss. We performed a retrospective study
Cristina L Esteves et al.
The Journal of clinical endocrinology and metabolism, 99(1), E160-E168 (2013-11-19)
Levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regenerates active glucocorticoids, are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both conditions associated with chronic low-grade inflammation. 11β-HSD1 expression is induced by proinflammatory cytokines in a variety
Saori Itoi et al.
Biochemical and biophysical research communications, 440(2), 265-270 (2013-09-24)
The endogenous glucocorticoid, cortisol, is released from the adrenal gland in response to various stress stimuli. Extra-adrenal cortisol production has recently been reported to occur in various tissues. Skin is known to synthesize cortisol through a de novo pathway and
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